MEDICINAL CHEMISTS (Multiple openings/Multiple companies) Job Code RA-01.
MISSION STATEMENT: Participate in drug discovery program(s).
RESPONSIBILITIES: Independently proposes, designs and conducts synthetic organic chemistry reactions to meet project goals. Synthetic work will encompass the preparation of single compounds as well as libraries. Purifies and characterizes materials by analytical methods such as NMR, HPLC, LC-MS. Maintains accurate and up-to-date experimental data. Produce high quality work. Possess strrong presentation skills. Work as part of a project.
QUALIFICATIONS: Broad range of chemistry experience including design and implementation of chemistries and transformations; Experience in the synthesis of pharmaceutically relevant compounds; Milligram to multigram scale experience; Experience in scale-up and physical chemical analysis of small therapeutics, especially NMR, IR, LC-MS; Track record of independent technical problem solving; Familiarity with automation and computationally proficient; BS, MS in Chemistry
NEW TARGET DISCOVERY: Job Code RA-02
This discovery group is looking for a highly motivated individual with strong technique skills in cell culture and / or antibody-assays. Responsibilities include performing cell culture and immunoassays to generate and characterize monoclonal antibodies for cancer research and therapeutics. A desire to learn, and the ability to work independently under the supervisor’s guidance are essential. The successful candidate should have a B.S. or M.S. in Biology / Immunology or related field in biomedical research. Experience with monoclonal antibody technique or flow cytometry is desirable.
ASSAY DEVELOPMENT: Job Code RA-03
This Company is in search of a motivated individual to perform cell based and immunochemical assays to support research and development of cancer therapeutics. Responsibilities will include: generating data from sample testing, providing written and oral reports, supporting laboratory activities and documentation needs. A qualified candidate will possess a Bachelors degree in Biology, Biochemistry or related field with 0-2 years experience in performing routine ELISA, FACS, and/or cell based cytotoxicity or functional assays.
CELL BIOLOGY: Job Code RA-04
This Company is in search of an experienced cell/molecular biologist. The incumbent will be responsible for maintaining various cell lines in the culture, expressing and purifying recombinant protein from cells, and implementation of in vitro and in vivo assays to evaluate the efficacy of novel proteins. This candidate should also be experienced in ELISA. Additionally, the candidate should have molecular biology experience. The position requires a BS with 4+ years of experience or a MS with 2+ years (industry experience preferred).
ANALYTICAL CHEMIST: Job code RA-05
This Company is focused on the discovery and development of biopharmaceutical therapeutics and vaccines for human disease. A qualified candidate should be hands on and familiar with applying various analytical techniques such as HPLC, SEC, AAA, Sequencing, Peptide Mapping, Light Scattering, Carbohydrate Analysis, SDS-PAGE, IEF and MS.. Experience / Education should include a BS/MS with 3+ years of relevant industry experience.
FORMULATION DEVELOPMENT: Job Code RA-06
This well funded biopharmaceutical company is recruiting for a qualified protein formulation associate. Your responsibilities will include: Conduct pre-formulation and formulation studies (liquid and solid state) for protein biopharmaceuticals to support pre-clinical testing and clinical trials. Identify and evaluate suitable conditions and excipients that preserve protein structure and activity under optimal commercially viable conditions; Set-up and conduct experiments to monitor accelerated and real-time stability of protein biopharmaceuticals; Develop / implement appropriate analytical methods to monitor protein stability and activity; Characterize protein degradation products by various biochemical and physico-chemical methods; Evaluate new formulation/delivery system manufacturing processes; Assist in authoring, editing and/or reviewing qualification / validation documentation, manufacturing process protocols and master batch records; Analyze, interpret and communicate experimental data to project teams in the form of oral presentations and written technical reports. What Experience / Education is required? B.S. / M.S. in a related discipline with 3+ years in the following areas: Experience in pre-formulation / formulation for protein drugs is essential; Thorough knowledge of protein structure and function; Hands-on experience in a broad range of protein analytical techniques including HPLC, spectroscopy (UV, Fluorescence, CD, light scattering), gel electrophoresis, DSC, etc.. In the plus or desirable area: experience with lyophilization; with development of oral dosage forms and experience in cGMP / cGLP environment.
BIOANALYTICAL CHEMIST: Job Code RA-07
As part of the PreClinical Drug Development group, you will be involved in method development and validation for the quantitation of small molecule compounds. Your experience should include working with HPLC and Mass Spec. Your research will involve you in analysis of the plasma and metabolic stability of compounds and quantitation of compounds from blood and plasma matrices for PK analysis. This is an exciting growing group in an exciting growing Company!
